ORAL PATHOLOGY: Neurofibroma

Neurofibroma:
It mat appear as solitary or multiple lesions
Etiology: - Solitary type is unknown - Neurofibromatosis is inherited
Clinical features:
Solitary type Uniflamed asymptomatic submucosal mass
Location: Tongue, vestibule & buccal mucosa
Multiple Café-au-lait macules Bone abnormalities (cortical erosion or medullary resorption)
Central nervous system changes
Pain or parasthesia may be seen
Malignant degeneration into neurogenic sarcoma is seen in 5% to 15%
histopathology: Spindle-shaped cells in connective tissue matrix
It may be well circumscribed or blended into surrounding connective tissue
Mast cells are scattered
Immunohistochemistry with S-100 is a useful tool to confirm diagnosis
Treatment: Surgical excision for solitary lesion Lack of encapsulation