ORAL PATHOLOGY: Leiomyoma & leiomyosarcoma

(Leiomyoma & leiomyosarcoma):
Smooth muscle neoplasms are relatively common
They may arise anywhere in the body
Leiomyoma
Leiomyomas are commonly arise in the muscularis of the gut and uterus
Oral leiomyoma is slow growing & asymptomatic submucosal masses
Appears in the tongue, hard palate or buccal mucosa Spindle cells
Appears at any age Pterygo-mandibular space
Histopathology: Immunohistochemical demonstration of actin and desmin protein expression can confirm diagnosis Obvious vascular origin Vascular leiomyoma Limited & uniform proliferation around each of the vascular spaces

 

Leiomyosarcoma
It is commonly arise in the retroperitoneum, mesentery, or subcutaneous and deep tissue of the limbs
It may appear at any age
Immunohistocemistry can be a valuable diagnostic tool
Treatment: wide surgical excision
Metastasis is not uncommon Blunt ended nuclei